The nucleoside analogues resemble naturally occurring nucleosides and act by causing termination of the nascent DNA chain. The widely used vasodilator and antiarrhythmic agents, hydralazine [38], and procainamide [39], have been Nucleoside analog inhibitors have figured prominently in the search for effective antiviral agents. The nucleoside analogues are an important class of antiviral agents now commonly used in the therapy of human immunodeficiency virus (HIV) infection, hepatitis B virus (HBV), cytomegalovirus (CMV) and herpes simplex virus (HSV) infection. The search of non-nucleoside analogs is encouraged because of the myelotoxic effects of the nucleoside analogs (molecules that act like nucleosides in DNA synthesis) [18]. CONCLUSION The synthesis of so-called L-nucleosides has provided a renewed interest in nucleoside analogs as a class of antiviral agents. Studies on the biochemistry and cellular pharmacology of these compounds have been in general quite rewarding. Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years Hanadi Sinokrot, Tasneem Smerat, ... protides and nucleoside analogues, and non-nucleoside analogues prodrugs), the most promising are ... antiviral agents [6–12], this review aims to explore strategies employed by researchers in … Nucleoside analogues are antiviral chemotherapeutic agents, which exhibit their "antiviral effect" primarily while viral replication is active at the host-cell level. The nucleoside analogues are an important class of antiviral agents now commonly used in the therapy of human immunodeficiency virus (HIV) infection, hepatitis B virus (HBV), cytomegalovirus (CMV) and herpes simplex virus (HSV) infection. VIII. Nucleoside analogs Nucleoside analogues are the major class of antiviral agents used for the management of Herpes Simplex Virus infections.